The brewery will open its doors to the public on the second May Bank Holiday weekend (27/28/29 May) with a street food and craft beer pop-up event.
Director of the brewery, Dave Stone, said: "It’s extremely exciting for us to be able to announce our opening dates along with the initial programme of events and live music shows at our new home at the Palace of Arts. We look forward to opening the doors to this incredible and historically important building."
"It has been almost a decade since anyone has had the opportunity to visit the Palace of Arts and we have taken great pride and care in bringing the building back to life."
The Palace of Arts will also play host to The North East Brewers Market, which is programmed by local festival Craft Beer Calling, bringing together the region's brewing community under on roof.
The £1.5m project has seen the brewery - which makes the award-winning Jakehead IPA - spend £750,000 on brewing equipment and the remainder on refurbishing the venue.
"There are some incredible microbreweries in the North East and the quality and diversity of beers being produced is at an all time high. We feel it’s important for the regions talented brewers to have a collaborative platform in which to present their beers.
"The North East Brewers Market will assist in raising the profile and awareness of the incredible beer scene we have here." Stone said.