Planning Solutions Limited will start brewing the award-winning White Shield IPA and Red Shield Beers having previously bought brewing equipment from Molson Coors earlier this year.
It will also run the National Brewing Centre in Burton-on-Trent on behalf of Molson Coors, where the beers are also being brewed in the William Worthington brewery.
The site will be under the ownership of Molson Coors, with PSL leasing the building.
PSL has said it aims to put significant investment into the site, which includes plans such as a refurbishment and modernisation as well as allowing head brewer, Steve Wellington, to develop new beers as part of his role.
Burton MP and chair of the parliamentary Beer Group, Andrew Griffiths, welcomed the move, stating he was 'delighted' that it would continue to provide local jobs - and brew one of his favourite beers.
Michael Stickland, chairman of PSL, told local paper, the Burton Mail: ""The sale of the brewery assets to PSL allows us to build on this heritage, continue to deliver the award-winning cask Worthington's White Shield IPA and Red Shield beers, as well as giving us the opportunity to explore other brewing opportunities to grow and sustain the future of this brewery."
Victoria Segebarth, supply chain director at Molson Coors UK & Ireland, also told the paper: "PSL already run the National Brewery Centre so this agreement is a natural step in the sustained success of the centre and we are confident that PSL will continue to produce extraordinary beer brands that delight customers and consumers."