Chapman, who has also helped the Royal Oak in Paley Street gain three AA rosettes during his seven years at the pub, told the Publican’s Morning Advertiser that, having recently turned 40, he felt "the time was right to manage his own business".
He claimed to be in the process of acquiring the leasehold of a food-led pub, also in Berkshire.
He said: "Being an employee at the Royal Oak has been an incredible experience for me, but at my stage of life I’m now ready for a new challenge.
"The property I’m looking to take on will allow me to run a classic British gastropub, offering high quality cuisine in a relaxed and friendly environment."
Immensely proud
A Fuller’s tenanted pub, the Royal Oak is run by Nick Parkinson – son of Sir Michael Parkinson – and Chapman said he is immensely proud of the business he is leaving.
Parkinson also opened the Belgian Arms in Holyport, near Maidenhead, Berkshire last year.
Chapman added: "There is a superb team in place, and they are fully deserving of their Michelin star. In sous chef Michael Chapman, the kitchen is being left in more than capable hands."
Chapman, who has also previously worked at Heston Blumenthal’s three-Michelin-starred Fat Duck, in Bray, is currently appearing in the latest BBC Great British Menu series, with his regional heat airing every day this week until Friday (25 April).
He said: "The series has been great fun, and I’d be happy to return to it again if asked."