The campaign will increase awareness of its seven all-you-can-eat theme nights across national print, regional radio and online as well as individual promotion on site until 15 July.
A voucher for bottomless soft drinks will run during the campaign.
Comedian Jason Manford stars across five 40-second regional radio adverts. Theme nights at the brand include Tex Mex and pie night from £5.99.
Emma Price, marketing manager at Brewers Fayre, said: “Variety is what our theme nights at Brewers Fayre are all about and we wanted to reflect this in an engaging way through our biggest ever national advertising campaign.
"Variety show line ups are famously diverse in skills, personalities and talents — and this is the idea we have drawn on to communicate the variety in our offering.”